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Overexpressing Notch1 in Tregs unlocks T cell proliferation

By stojdllab, Nov 16 2015 10:33PM

Tumours typically recruit regulatory T cells (Tregs) to suppress the activity of other T cells. This effectively prevents T cells from targeting - and destroying - the tumour. Now, a team of scientists from Harvard Medical School have shown that overexpressing a fragment of a protein called Notch 1 in Tregs reverses their activity - and helps them promote T cell function. Although this team's research is based in a model of immune tolerance, it has key (positive) implications for cancer immunotherapy strategies.


You can read the original research paper in full here.


Image credit: Scientific Illustration for the Research Scientist

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